Quercetin as a shuttle for labile iron.

Quercetin attenuates chronic ethanol hepatotoxicity: implication of "free" iron uptake and release.

Emerging evidence has displayed that oxygen free radicals especially ones promoted by "free" iron play an important role in the development of alcoholic liver disease (ALD). Naturally-occurring quercetin has been reported to prevent ALD and iron overload-induced damage aside from the "free" iron. The purpose was to explore the potential mechanisms by which quercetin arrests alcohol-induced "fre...

Histopathological effects of quercetin on liver tissue damage induced by iron oxide and iron oxide nanoparticles in Wistar rats

Introduction: Industrial and environmental pollution, excessive iron supplementation and blood transfusion are among the factors that may cause iron toxicity. Therefore, it is necessary to identify the mechanisms influencing or protecting against iron toxicity. The present study aimed to investigate the protective effects of quercetin as an antioxidant on hepatotoxicity induced by iron oxide an...

Existence of an Erythropoitic labile iron pool

The Effect of Quercetin on Learning and Memory Deficit, Lipid Peroxidation, and Cholinesterase Activeity Following Lipopolysaccharide in the Rat

Background and Objective: Lipolysaccharide (LPS) is a large molecule isolated from bacteria such as the enterobacteriaceae family with a negative effect on memory and learning through disturbing the balance of free radicals and creating oxidative stress conditions. In this study, we evaluated  the effect of quercetin on oxidative stress and LPS-induced memory impairment in the rat. Materials a...

Quercetin Inhibits Intestinal Iron Absorption and Ferroportin Transporter Expression In Vivo and In Vitro

Balancing systemic iron levels within narrow limits is critical for maintaining human health. There are no known pathways to eliminate excess iron from the body and therefore iron homeostasis is maintained by modifying dietary absorption so that it matches daily obligatory losses. Several dietary factors can modify iron absorption. Polyphenols are plentiful in human diet and many compounds, inc...